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Background: Acne vulgaris is a dermatological disorder characterised by formation of comedones and inflammatory lesions. The treatment of acne basically involves reduction of lesions and prevention of permanent scarring. The current line of treatment for mild to moderate acne is topical medications with antimicrobials and retinoids. The present study assessed the efficacy and safety of adapalene in comparison to benzoyl peroxide-clindamycin combination that whether it is better than the benzoyl peroxide-clindamycin combination for topical treatment of mild to moderate acne vulgaris.
Methods: In this study, the patients with mild to moderate acne vulgaris were divided into two groups, one group was treated with topical adapalene whereas topical benzoyl peroxide-clindamycin combination was given to the other group.
Assessment of efficacy was done by total lesion counting while safety assessment was done by noting the adverse drug reactions due to medication, the results were compared at the end of 1, 2 and 3 months with the baseline values.
The tolerability profile of adapalene was comparatively better than benzoyl peroxide-clindamycin combination. Conclusions: Adapalene is as efficacious as benzoyl peroxide-clindamycin combination to treat mild to moderate acne vulgaris, but it is comparatively better tolerated than benzoyl peroxide-clindamycin combination.
Emil A. The role of inflammation in the pathology of acne. J Clin Aesthet Dermatol. Comparison of clinical efficacy of topical clindamycin with adapalene and adapalene alone in treatment of mild to moderate facial acne vulgaris. Int J Pharm Bio Sci. Dutil M. Benzoyl peroxide: enhancing antibiotic efficacy in acne management.
Skin Therapy Lett. Persy SH. Safety and efficacy of adapalene gel 0. Indian J Dermatol Venereol Leprol. Scoring systems in acne vulgaris. Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: a randomized controlled trial. Indian J Pharmacol. Adapalene pretreatment increases follicular penetration of clindamycin: In vitro and in vivo studies.
Efficacy and safety of a nano-emulsion gel formulation of adapalene 0. Indian J Dermatolo Venereol Leprol. Randomised, controlled trial of the efficacy and safety of adapalene gel 0. Eur J Dermatol. Comparative irritancy study among retinoid creams and gels. J Cutan Med Surg. Randomized, controlled, bilateral split-face comparison trial of the tolerability and patient preference of adapalene gel 0.
Topical adapalene gel 0. Br J Dermatol. Comparative evaluation of effectiveness of adapalene and azithromycin, alone or in combination, in acne vulgaris.
Indian J Dermatol. User Username Password Remember me. Font Size. Notifications View Subscribe. Article Tools Print this article. Indexing metadata. How to cite item. Finding References. Email this article Login required. Comparison of efficacy and safety of adapalene and benzoyl peroxide-clindamycin combination in the topical treatment of acne vulgaris. Abstract Background: Acne vulgaris is a dermatological disorder characterised by formation of comedones and inflammatory lesions.
Keywords Pilo-sebaceous unit, Comedones, Antimicrobials, Retinoids. Full Text: PDF. References Emil A. Selway J. The psychosocial impact of acne and rosacea. Adv Stud Nurs. Rathi SK. Acne vulgaris treatment: The current scenario. Acne and its treatment lines. Int J Res Pharma Bio. Kraft J, Freiman A. Management of acne. Remember me.
Pregnancy acne: What's the best treatment? - Mayo Clinic.
Pregnancy acne isn't a special form of acne. Some people simply seem to have trouble with acne during pregnancy. The likely culprit is an excessive production of oil sebum — which happens when the body produces greater amounts of certain hormones.
Medication also can be used to treat pregnancy acne. However, medications applied to the skin or swallowed during pregnancy can enter your bloodstream and affect the baby. While most ingredients in topical acne treatments available without a prescription haven't been studied in pregnancy, typically only small amounts are absorbed into the skin. This makes it unlikely that the treatments would pose a risk to a developing baby.
Generally, skin treatments containing erythromycin Erygel, Erythra-Derm and clindamycin Cleocin T, Clindagel, others are considered safe. Other options include treatments containing benzoyl peroxide and azelaic acid. Some acne medications are known to cause birth defects and must be avoided during pregnancy, including oral isotretinoin Amnesteem, Claravis, others. Also avoid topical retinoids during pregnancy even though only low amounts of the medication are absorbed into the skin.
Retinoids are available with and without a prescription, so read drug labels carefully. If you're concerned about pregnancy acne, consult your health care provider. Together you can weigh the benefits and risks of various treatment options. Lawrence E. Gibson, M. There is a problem with information submitted for this request. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID, plus expertise on managing health.
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This content does not have an English version. This content does not have an Arabic version. See more conditions. Request Appointment. Healthy Lifestyle Pregnancy week by week. Products and services. What's the best way to treat pregnancy acne?
Answer From Lawrence E. With Lawrence E. Thank you for subscribing! Sorry something went wrong with your subscription Please, try again in a couple of minutes Retry. Show references Isotretinoin Accutane. Accessed March 23, Mattison D, et al. Management of dermatological conditions in pregnancy. In: Clinical Pharmacology During Pregnancy. Elsevier; Acne: Tips for managing.
American Academy of Dermatology. Topical acne treatments. Reszko A, et al. Postadolescent acne in women. Landon MB, et al. Skin disease and pregnancy. FAQs: Skin conditions during pregnancy. American College of Obstetricians and Gynecologists. See also Air travel during pregnancy Allergy medications during pregnancy Ankle swelling during pregnancy Antibiotics and pregnancy Aspirin during pregnancy Baby brain Pregnancy back pain Falling during pregnancy: Reason to worry? Flu and pregnancy Flu shot in pregnancy Headaches during pregnancy: What's the best treatment?
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